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Immunity and vaccine development efforts against Trypanosoma cruzi.
Rios LE, Vázquez-Chagoyán JC, Pacheco AO, Zago MP, Garg NJ. Rios LE, et al. Acta Trop. 2019 Dec;200:105168. doi: 10.1016/j.actatropica.2019.105168. Epub 2019 Sep 9. Acta Trop. 2019. PMID: 31513763 Free PMC article. Review.
In this review, we summarize the research efforts in vaccine development to date and the challenges faced in achieving an efficient prophylactic or therapeutic vaccine against human CD....
In this review, we summarize the research efforts in vaccine development to date and the challenges faced in achieving an efficient prophyla …
Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease.
Beltran-Hortelano I, Alcolea V, Font M, Pérez-Silanes S. Beltran-Hortelano I, et al. Bioorg Med Chem. 2022 Mar 15;58:116577. doi: 10.1016/j.bmc.2021.116577. Epub 2022 Feb 1. Bioorg Med Chem. 2022. PMID: 35189560 Free article. Review.
Despite the continuous efforts of many organizations and institutions, CD is still an important human health problem worldwide. A lack of a safe and affordable treatment has led drug discovery programmes to focus, for years, on the search for molecules enabling inte …
Despite the continuous efforts of many organizations and institutions, CD is still an important human health problem worldwide. A lac …
Trypanothione Reductase and Superoxide Dismutase as Current Drug Targets for Trypanosoma cruzi: An Overview of Compounds with Activity against Chagas Disease.
Beltran-Hortelano I, Perez-Silanes S, Galiano S. Beltran-Hortelano I, et al. Curr Med Chem. 2017 May 31;24(11):1066-1138. doi: 10.2174/0929867323666161227094049. Curr Med Chem. 2017. PMID: 28025938 Review.
This review will focus on two of the most promising targets for the therapy of CD: trypanothione reductase (TR) and the iron-containing superoxide dismutase (Fe- SOD), which protect the parasite against oxidative damage by reactive oxygen species. A brief comparison of the …
This review will focus on two of the most promising targets for the therapy of CD: trypanothione reductase (TR) and the iron-containi …
Recent developments in trans-sialidase inhibitors of Trypanosoma cruzi.
Kashif M, Moreno-Herrera A, Lara-Ramirez EE, Ramírez-Moreno E, Bocanegra-García V, Ashfaq M, Rivera G. Kashif M, et al. J Drug Target. 2017 Jul;25(6):485-498. doi: 10.1080/1061186X.2017.1289539. Epub 2017 Feb 20. J Drug Target. 2017. PMID: 28140698 Review.
Trypanosoma cruzi trans-sialidase is an enzyme that is of vital importance for the survival of the parasite due to its key role in the transfer of sialic acid from the host to the parasite surface and it also helps the parasite combat the host's immune system. This enzyme has no …
Trypanosoma cruzi trans-sialidase is an enzyme that is of vital importance for the survival of the parasite due to its key role in the trans …
Repositioning of HIV Aspartyl Peptidase Inhibitors for Combating the Neglected Human Pathogen Trypanosoma cruzi.
Sangenito LS, Menna-Barreto RFS, d'Avila-Levy CM, Branquinha MH, Santos ALS. Sangenito LS, et al. Curr Med Chem. 2019;26(36):6590-6613. doi: 10.2174/0929867326666190610152934. Curr Med Chem. 2019. PMID: 31187704 Review.
The changes in its epidemiology facilitate co-infection with the Human Immunodeficiency Virus (HIV), making even more difficult the diagnosis and prognosis. ...In this sense, the repositioning of approved drugs appears as an interesting and viable strategy. The discovery o …
The changes in its epidemiology facilitate co-infection with the Human Immunodeficiency Virus (HIV), making even more difficult the d …
Theft and Reception of Host Cell's Sialic Acid: Dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like Molecules on Chagas' Disease Immunomodulation.
da Fonseca LM, da Costa KM, Chaves VS, Freire-de-Lima CG, Morrot A, Mendonça-Previato L, Previato JO, Freire-de-Lima L. da Fonseca LM, et al. Front Immunol. 2019 Feb 6;10:164. doi: 10.3389/fimmu.2019.00164. eCollection 2019. Front Immunol. 2019. PMID: 30787935 Free PMC article. Review.
Much of that information pertains to their role on the immune system and their importance on the surface of many human pathogens. A clear example of this is the flagellated protozoan Trypanosoma cruzi, which displays on its surface a great variety of glycoconjugates, inclu …
Much of that information pertains to their role on the immune system and their importance on the surface of many human pathogens. A c …
Trypanosoma cruzi trans-sialidase as a drug target against Chagas disease (American trypanosomiasis).
Miller BR 3rd, Roitberg AE. Miller BR 3rd, et al. Future Med Chem. 2013 Oct;5(15):1889-900. doi: 10.4155/fmc.13.129. Future Med Chem. 2013. PMID: 24144418 Review.
Trypanosoma cruzi, the parasitic cause of Chagas disease, possesses a membrane-anchored trans-sialidase enzyme that transfers sialic acids from the host cell surface to the parasitic cell surface, allowing T. cruzi to effectively evade the host's immune system. This enzyme has no …
Trypanosoma cruzi, the parasitic cause of Chagas disease, possesses a membrane-anchored trans-sialidase enzyme that transfers sialic acids f …
Expanding the tool box for genetic manipulation of Trypanosoma cruzi.
Burle-Caldas Gde A, Grazielle-Silva V, Laibida LA, DaRocha WD, Teixeira SM. Burle-Caldas Gde A, et al. Mol Biochem Parasitol. 2015 Sep-Oct;203(1-2):25-33. doi: 10.1016/j.molbiopara.2015.10.004. Epub 2015 Oct 30. Mol Biochem Parasitol. 2015. PMID: 26523948 Review.
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, an illness that affects 6-7 million people and for which there is no effective drug therapy or vaccine. The publication of its complete genome sequence allowed a rapid advance in molecular studies …
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, an illness that affects 6-7 million people and for which there is no e …
CD8+ T cells in Trypanosoma cruzi infection.
Padilla AM, Bustamante JM, Tarleton RL. Padilla AM, et al. Curr Opin Immunol. 2009 Aug;21(4):385-90. doi: 10.1016/j.coi.2009.07.006. Epub 2009 Jul 29. Curr Opin Immunol. 2009. PMID: 19646853 Free PMC article. Review.
CD8(+) T cells have emerged as crucial players in the control of a number of protozoan pathogens, including Trypanosoma cruzi, the agent of human Chagas disease. The recent identification of the dominant targets of T. cruzi-specific T cells has allowed investigators to fol …
CD8(+) T cells have emerged as crucial players in the control of a number of protozoan pathogens, including Trypanosoma cruzi, the agent of …
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